Vitamin K2 Mk-4 (Menatetrenone) Supplement Powder

• CAS No.: 2124-57-4
• Formula: C46h64o2
• Packaging Material: Paper
• Storage Method: Normal
• Shelf Life: >12 Months
• Nutrient Composition: Vitamin
• Model NO.: 98%
• Resource: Chemosynthesis
• The content of active substances: 0%~30%
• Transport Package: 25kg/Drum
• Specification: 25kg/drum
• Origin: China
• HS Code: 2936290090
• Production Capacity: 1000kg/Year

Product Description

Vitamin K2 Mk-4 (Menatetrenone) Supplement Powder 

Product Description :
Vitamin K2 is part of the Vitamin K family, a group of fat-soluble vitamins.(That means they are stored in the gastrointestinal tract and delivered to body in fat globules call chylomicrons.)You have probably heard of Vitamin K, which is crucial for the production of proteins that we need for coagulation, or blood clotting. Without Vitamin K, we would not stop bleeding. That connection was discovered in 1929,and it earned Henrik Dam and Edward Doisy the Nobel Prize in 1943.
Vitamin k2 mk7 bioavailability in the extrahepatic tissues is higher.
Vitamin K2 is a naturally occurring vitamin that contains the basic structure of menadione and has anti bleeding effects. It is a yellow crystal or oily liquid at room temperature, insoluble in water, easily soluble in organic solvents and vegetable oils, heat-resistant, but easily damaged by light. It can promote the synthesis of prothrombin in the liver, regulate the synthesis of coagulation factors VII, IX, and X, thereby accelerating blood coagulation. In addition, glucose phosphorylation plays an important role in cells. In certain bacteria (such as Mycobacterium), it can serve as a component of the respiratory chain. After deficiency, the clotting time prolongs, so when there is trauma, there will be continuous bleeding. Bacteria in the intestines of humans and animals can synthesize, so they are generally less susceptible to deficiency. Liver, fish, meat, and green leafy vegetables such as cabbage and spinach are rich in content. This product can be synthesized by microorganisms, including animal gut bacteria, and can also be extracted from spoiled fish meal. Vitamin K is physiologically related to coagulation. The name of vitamin K comes from the first letter of Koagulation, which means "coagulation". Natural vitamin K has two groups of chemical compounds, namely chlorophyllin quinones (vitamin K1) and methyl naphthoquinones (vitamin K2). The former exists in green leafy plants, and the latter is synthesized by bacteria. The artificially synthesized compound menadione, namely α- Methyl-1,4 naphthoquinone is called vitamin K3. This cyclic compound is the basic structure of the natural vitamin K family, and its biological activity is higher than that of vitamins K1 and K2. Vitamin K is stable to heat, but easy to be damaged by light and alkali, so it should be kept away from light. The absorption of vitamin K requires bile and pancreatic juice. The labelled chlorophyllin test proves that the absorption rate of vitamin K in normal people is about 80%, while that in fat malabsorption patients is 20~30%. The absorbed vitamin K is sent into the blood by lymphatic chyle particles β- Lipoprotein runs together in the blood. Vitamin K appears in large quantities in the liver 1~2h after ingestion, and other tissues such as kidney, heart, skin and muscle also increase, and decrease after 24h. Human intestinal bacteria synthesize vitamin K, and some of it can be used by human body, becoming an important source of human vitamin K.
Vitamin K2 (MK-7), a type of vitamin K2, contains 7 isoprene units on the side chain of vitamin K2. It is a fat soluble vitamin and one of the essential and important vitamins in the human body.
Physical and chemical properties
CAS:2124-57-4;
1. Molecular structure
2. Source
Vitamin K2 (MK-4): mainly from meat
Vitamin K2 (MK-7): mainly from natto
3. Absorption and transportation
Vitamin K2 (MK-7) is mainly redistributed in the liver through low-density lipoprotein;
Vitamin K2 (MK-4) is rapidly cleared in the liver using the same lipoprotein as the carrier.
4. Bioavailability
Research has shown that the side chain of vitamin K2 (MK-7) is longer than that of vitamin K2 (MK-4), which can exist in the human body for a longer time and has a higher bioavailability in extrahepatic tissues.
5. Effective usage level
Vitamin K2 (MK-7) belongs to μ G/d level (microgram level), once every full wedding preparation day, 90 micrograms each time;
Vitamin K2 (MK-4) belongs to the recommended dosage of mg/d (milligram level), which is taken three times a day, with 15 milligrams per dose (equivalent to 45000 micrograms of drilling and sweating per day). The required dosage is 500 times that of vitamin K2 (MK-7). Abstinence from ejaculation
6. Production process
Vitamin K2 (MK-7): can be naturally extracted or obtained through chemical synthesis
Vitamin K2 (MK-4): obtained through chemical synthesis
Application :
(1) treatment and prevention of osteoporosis, vitamin K2 generate bone protein, and then together with the calcium of bone formation, increase bone density and prevent fractures.                                                                          
(2) Vitamin K2 can prevent progression to liver cirrhosis.
(3) the lack of treatment of hemorrhagic disease of vitamin K2, and promote the formation of prothrombin, accelerated blood clotting, maintain normal clotting time.  
(4) with a diuretic, strengthen the liver's detoxification function, and can lower blood pressure.